This cross-sectional research study in Vietnam examined the acceptability of the coronavirus 19 (COVID-19) vaccine among nursing students and factors that influenced their vaccination experience. Results showed that 86.2% of the study sample accepted COVID-19 vaccination. Vaccine safety, unavailability of vaccines, and governmental information were major determinant factors in their acceptance. Confirmed safety, greater vaccine availability, and accurate public information through government and social media networks may increase the acceptance of the vaccine and contribute to future COVID-19 vaccination programs in Vietnam.