Invasive mole is a common disease among Gestational trophoblastic diseases. The frequency of invasive mole ranks second after noninvasive mole. Invasive pregnancy destroys the uterus, invades blood vessels and metastasis to another organs. Invasive moles mostly occur in women of reproductive age, while they are extremely rare in perimenopause and postmenopause. Therefore, we report a rare case diagnosed with
invasive mole at 55 years old. Case presentation: Female, perimenopausal age, prolonged bleeding, no
history of mole or abnormal abortion. ßHCG is higher than normal. Ultrasound and post-operative pathology
showed the following results: uterus and vascular invasion. FIGO stage I with a score according to 2000
FIGO is 10 points, belonging to the group with high risk factors. After surgery and chemotherapy with
Methotrexat x4 cycles. The patient responded well to chemotherapy. Conclusion: Invasive pregnancy is
rare in perimenopausal patients. Diagnosis is based on ultrasound, ßHCG and histopathological results.
Treatment is mainly surgery and chemotherapy. The disease responds particularly well to chemotherapy.
The disease has a good prognosis because of its response to chemotherapy.