Abstract: Helicobacter pylori (H. pylori) is a main  cause of gastritis, peptic ulcer and gastric malignancies. H. pylori still remains a challenge dute to antibiotics resistance.  A triple rescue regimen containing levofloxacin is a potential alternative; however, resistance to quinolones is rapidly increasing.Materials and Method: Prospective study on 61 patients (who failured to the fist line therapy) were cured by this regimen (Pantoprazol + Amoxicillin + Levofloxacin) for 28 days. Results: the eradication rate was 83.6%. The rate of eradication of the group with one of ulcer and realease symptom are sinificantly higher than that of above one and no realease symtom ( P<0,05). Conclusion: This regimen is effective. Release of symptom and the number of ulcers are the prognostic factors in the treatmen result