Diagnostic values of different cytokines in identifying tuberculous pleural effusion
Huong Bui Thi Thu, , , Mar-2020, In: Tropical Biomedicine, 37, 2, p. 372-378
, Overview
Abstract:
Abstract. Interleukin (IL)-1 beta (IL-1β), IL-2, Interferon-gamma (IFN-γ), tumor necrosis
factor-alpha (TNF-α) in the pleural fluid are valuable biomarkers in early diagnosis of
Tuberculous Pleural Effusion (TPE). This study aimed to analyze the diagnostic values of
some cytokines (IFN-γ, TNF-α, IL-1β, and IL-2) in pleural fluid for identifying TPE in Vietnam.
We performed a cross-sectional study on tuberculosis (TB) patients with pleural effusion.
Pleural IFN-γ, TNF-α, IL-1β, IL-2 were measured by ELISA® Kit (Abcam, USA) on Biotek
system. Receiver operating characteristic curves (ROC), an area under the curve (AUC),
sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value
(NPV) and accuracy (ACC) of IFN-γ, TNF-α, IL-1β, IL-2 in identifying TBE were assessed.
Among 386 patients, 234 (60,6%) had TPE, and 152 (39,4%) did not have TPE. The median of
IL-2, TNF-α, and IFN-γ levels were significantly higher in TPE compared to the non-TPE
group (p<0.05). AUC for IL-1β, IL-2, TNF-α, and IFN-γ were 0.54, 0.57, 0.62. 0.84 (p<0.05),
respectively. The sensitivity of IL-1β, IL-2, TNF-α, and IFN-γ in the diagnosis of TPE were
82.1, 53.4, 77.8, and 80.3, while the specificity was 28,4, 69.7, 47.4, and 80.9, respectively.
IFN-γ and TNF-α are potential biomarkers in diagnosing TPE
Pages (from-to) | 372-378 |
Journal | Tropical Biomedicine |
Volume | 37 |
Issue number | 2 |
Publication status | Published - Mar-2020 |
ISBN | 0127-5720 |