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Does sperm DNA fragmentation correlate with semen parameters?
Home Research Publications Does sperm DNA fragmentation correlate with semen parameters?

Does sperm DNA fragmentation correlate with semen parameters?

Le Minh Tam, Tuyet Nguyen Thi Hiep, Nguyen Thi Tam An, Nguyen Van Trung, Nguyen Thi Thai Thanh, Le Dinh Duong, Nguyen Vu Quoc Huy, Cao Ngoc Thanh, Sep-2019, In: Reproductive Medicine and Biology, 18, 4, p. 390-396

Overview

  • Le Minh Tam
  • Tuyet Nguyen Thi Hiep
  • Nguyen Thi Tam An
  • Nguyen Van Trung
  • Nguyen Thi Thai Thanh
  • Le Dinh Duong
  • Nguyen Vu Quoc Huy
  • Cao Ngoc Thanh

Abstract:

Purpose

This study aimed to investigate the association between sperm quality assessed by routine semen analysis and sperm DNA integrity assay.

Methods

In our cross-sectional study, a total of 318 men from the infertile couples were enrolled from December 2017 to March 2019 at the Hue Center for Reproductive Endocrinology and Infertility, Vietnam. General characteristics and semen parameters were detected. The sperm DNA fragmentation index (DFI) was estimated by the sperm chromatin dispersion (SCD) assay. A threshold of DFI 30% was applied to classify normal (DFI < 30%) or abnormal (DFI ≥ 30%) groups. The correlations between DFI and semen parameters were analyzed by Spearman's rank correlation coefficient.

Results

In the correlation analysis, DFI was significantly correlated with abnormal head and progressive motility, with a positive correlation with abnormal head (ρ = .202, P = .0003) and a weak negative correlation with progressive motility (ρ = −.168, P = .0027), respectively. In the bivariate analysis, DFI was associated with male age, smoking, and alcohol consumption with P < .05.

Conclusions

The sperm DFI was not strongly correlated with conventional semen parameters. Therefore, a sperm DNA fragmentation assay should be performed as an additional step in the investigation of male fertility.

Keyword(s): Sperm DNA fragmentation, DNA fragmentation index, semen parameters, sperm chromatin dispersion

Pages (from-to) 390-396
Journal Reproductive Medicine and Biology
Volume 18
Issue number 4
Publication status Published - Sep-2019
ISBN 1447-0578