Introduction: The burden of chronic diseases is increasing rapidly all over the world. Supporting patients in self-management is an effective approach to manage chronic kidney disease and to slow the disease progress. Many factors have been identified that related to the self-management behavior of disease among people with chronic kidney disease.

            Objectives: To identify knowledge of chronic kidney failure level, the confidence and self-management behavior of disease among patients with chronic kidney failure; to study factors related to the self-management behavior of disease among patients with chronic kidney failure in Thai Nguyen National Hospital.

            Participants and method: A cross-sectional descriptive study was conducted among 150 patients with chronic kidney failure (who have not had dialysis) in Thai National Hospital. Data was collected using 3 questionnaires (V.KiKS, V.SECDS, V.CKD-SM).

            Results: Chronic kidney failure knowledge, confidence in the process of disease management, and self-management behavior of disease among patients with chronic kidney failure was moderate ( = 16,84. SD = 3,12;  = 37,32. SD = 1,31;  = 58,19. SD = 1,42). Factors related to to the self-management behavior of chronic kidney disease including: the duration of disease was related at a low level, while chronic kidney failure knowledge and confidence was correlated at a moderate level (r = 0,1; r = 0,45 và r = 0,34; p < 0,01).

            Conclusion: There is a need of providing chronic failure knowledge and enhance the confidence in the process of disease management to patients. The nurses should develop an education program of self-management behavior of disease to ensure the quality of patient’s care.