Abstract: With the objective is to assess some factors affecting the quality of life in psoriasis patients at the Dermatology Department of Thai Nguyen Central Hospital, the Author use the descriptive study, cross-sectional design on 40 psoriasis patients attending examination and treatment at Thai Nguyen Central Hospital from April 2023 to April 2024. Result is that: 100% of psoriasis patients were affected in terms of quality of life, with 70% being significantly or very significantly affected. The quality of life of severe psoriasis patients was most affected (DLQI 26.8±1.92). The group of patients not using biologic drugs had a higher DLQI compared to the group using biologic drugs (16.34±8.01 vs. 3.0±1.22 with p<0.05). Patients with psoriasis for over 10 years (DLQI: 9.42±4.58) were less affected in terms of quality of life compared to those with less than 5 years (22.31±8.08) and 5-10 years (12.27±7.43) with p <0.0001. There was no difference in quality of life between males and females, nor was there a correlation with the age group affected by the disease. The quality of life of psoriasis patients is related to the severity of the disease, duration of illness, and the medication being used.