In this research, the pellet containing diltiazem HCl has been initially

studied by layering method in fluid-bed machine. The formulation of

the pellets included avicel, lactose, binders and diltiazem. Pellets

containing ditiazem was prepared by layering drugs and excipients on

the inert core which was prepared in rotary processor. The diltiazem

pellets were coated with the layering drugs containing ditiazem in

fluid-bed machine to obtain pellets. The prepared pellets were

evaluated for drug content, particle size, subjected to Scanning

Electron Microscopy (SEM) and Differential Scanning Calori metry

(DSC), and evaluated for in vitro release. Diltiazem pellets achieved

good sphericity, low friability, narrow particle size distribution,

smooth surface, high efficiency and be able to control release the drug

well. From the research results, we have developed a formula for

preparing diltiazem pellets by the fluidized bed coating method from

inert cores and standards for pellets as a semi-finished product for

capsule or tablet filling or extended-release formulation