HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF HER2-POSITIVE BREAST CARCINOMA
Overview
Abstract:
HER2/neu expression plays an important role in the prognosis and treatment of breast cancer. HER2/neu overexpression occurred in both HER2-enriched and luminal HER2 subtypes. Purpose: Review some histopathological and immunohistochemical features of HER2/neu-positive breast carcinoma. Methods: 133 breast cancer patients were identified with overexpression of HER2/neu and determining the association with tumor grade, TNM stage, rick category, Ki67 index, Bcl2 status. Results: Grade III, HER2 subtypes (63,5%) had a higher rate than LUMBH+ (54,2%); Stage III, HER2 subtypes (25%) had a higher rate than LUMBH+ (21,3%); high risk, HER2 subtypes (49,4%) had a higher rate than LUMBH+ (45,8%); high Ki67, HER2 subtypes (48,2%) had a higher rate than LUMBH+ (45,8%); Bcl2 status, HER2 subtypes (21,2%) had a lower rate than LUMBH+ (68,8%). Conclusion: In HER2/neu-positive breast, HER2 subtypes has worse prognosis of some histopathological and immunohistochemical factors than LUMBH+.
Keyword(s): Breast cancer, Her2/neu, Ki67, Bcl2 marker, immunohistochemistry
Pages (from-to) | 321-326 |
Journal | Vietnam Journal of Oncology |
Issue number | 1 |
Publication status | Published - 2021 |
ISBN | 1859-400X |