Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam
Hoàng Thị Ngọc Trâm, , , , , , , , , , , , Phạm Thị Thùy, , Nguyễn Tiến Dũng, Huong Bui Thi Thu, May-2023, In: Clinica terapeutica, 174, 3, p. 266-274
Overview
Abstract:
Background. Hepatitis B virus (HBV) infection remains a major
public health problem. The interaction between HBV and the host inflammatory
response is an important factor contributing to liver damage
and disease development. We investigate of the correlation between
peripheral blood cell levels, HBV DNA, and the risk of transmission
to the baby in pregnant women infected with hepatitis B.
Methods. A multidimensional analysis was performed on data
collected from 60 Vietnamese pregnant women and their babies (cord
blood).
Results. Taking the risk ratio test results of cord blood HBsAg as a
positive probability, the boundary of maternal PBMC concentration is
8.03x106 cells/ml (with negative correlation) and for CBMCs is 6.64x106
cells/ml (with positive correlation). That means that HBsAg positivity in
the blood may be related to the increasing of CBMCs and the diminution
of maternal PBMCs. When the maternal viral load is higher than 5x107
copies/ml, the risk of being HBsAg-positive in cord blood is 123%
(RR=2.23 [1.48,3.36]); when the viral load is lower than this baseline,
the risk is decreased by 55% (RR=0.45 [0.30,0.67]) (p<0.001).
Conclusions. With several steps of the analysis, this study found
maternal peripheral blood cell levels and cord blood positively correlated
in pregnant women with a load lower than 5x107 copies of
HBV DNA/ml. The study’s results suggest that the role of PBMCs
and HBV DNA in vertical infection is essential.
Keyword(s): chronic hepatitis B virus infection, liver, pregnant women, cord blood, peripheral blood mononuclear cells, cord blood mononuclear cells
| Pages (from-to) | 266-274 |
| Journal | Clinica terapeutica |
| Volume | 174 |
| Issue number | 3 |
| Publication status | Published - May-2023 |
| ISBN | 0009-9074 |