Objectives: Describing clinical and endoscopic characteristics of colorectal polyps over 10mm in size and assessing the effectiveness and complications of endoscopic polypectomy. Subject and methods: A descriptive cross-sectional study on 121 patients at Vinh Phuc provincual general hospital from October 2022 to June 2023. Colonoscopy was performed to evaluate characteristics of polyps over 10mm in size and we perform the technique of cutting polyp using hot snare polypectomy, edoscopic musocal reception, endoscopic submusocal disseption, and plus injector, hemoclips or endoloop to stop and prevent bleeding. Complications were detected and treated during procedure. Result: Age: 59,22 ±14,11; The rate of polyps were seen most frequently at sigmoid colon (32,2%) and rectum (30,6%). Stalked polyps (77,7%). Polyp >2cm in size accounted for 31,4%. There were 95,0% neoplastic polyps. The rate of successful polypectomy was 100%. There was no case of perforation and 8 cases had bleeding but successfully treated by clipping. Conclusion: Colorectal polyps over 10mm in size are mainly adenomatous ones. Endoscopic polypectomy can be done successful and safe even for large colorectal polyp when we apply submucosal injection and using clip or endoloop to stop and prevent bleeding