Background: Sleep disorders, including snor‑ ing and obstructive sleep apnea (OSA), are sig‑ nificant health concerns. OSA affects an esti‑ mated 4 million (8.5%) individuals in Vietnam, with 2.3 million suffering from moderate-tosevere conditions. Despite the high prevalence, underdiagnosis and limited accessibility to sleep diagnostics remain challenges. This study aims to assess the feasibility and effectiveness of a guided, self-administered home sleep study using a level 3 diagnostic model. Methods: A cross-sectional multicenter survey conducted from September 2023 to March 2024 included healthcare professionals (HCPs) across Vietnam. Participants completed questionnaires (Epworth Sleepiness Scale, STOP-BANG), and high-risk individuals underwent respiratory polygraphy using ApneaLink Air devices. Stand‑ ardized instructions and technical support were provided remotely by trained technicians. Results: Out of 1721 participants, 21.9% were diagnosed with OSA, comprising mild (32.4%), moderate (19.6%), and severe cases (9.2%). Prevalent symptoms included insomnia (22.2%), daytime sleepiness (40.7%), and memory decline (49.4%). Technical issues were minimal, support‑ ing the feasibility of this approach. Conclusion: A level 3 home sleep study model is effective for large-scale OSA screening. Inte‑ grating such approaches into public health ini‑ tiatives can enhance early diagnosis and treat‑ ment access, reducing OSA-related health and economic burdens.