Objective: This study was conducted to evaluate the analgesic and anti-inflammatory effects of the ethanol extract from Ligustrum sinense Lour. in experimental animal models.

Subjects and Methods: The analgesic effect was evaluated using the acetic acid-induced writhing test and the hot plate test. To assess the anti-inflammatory effect, we used the carrageenan-induced acute inflammation model and the cotton pellet-induced granuloma model.

Results: The Ligustrum sinense extract at a dose equivalent to 10.8 g of crude drug/kg showed an analgesic effect in the acetic acid-induced writhing model. Furthermore, the extract at doses equivalent to 3.6 g/kg and 10.8 g of crude drug/kg in mice also showed an anti-inflammatory effect in the cotton pellet-induced granuloma model, evidenced by a reduction in both the wet and dry granuloma weights compared to the control group. The extract at doses of 1.8 g/kg and 5.4 g/kg in rats also demonstrated an anti-inflammatory effect in the carrageenan-induced paw edema model.

Conclusion: The ethanol extract from Ligustrum sinense Lour. possesses analgesic and anti-inflammatory properties, which may be beneficial in treating various diseases related to inflammatory processes.