Research with the aim of evaluating the acute toxicity and hepatoprotective effect of ethanol extract of stem bark of Oroxylum indicum (L.) Vent. Method was Determination of acute oral toxicity according to the Litchfield – Wilcoxon’s method; evaluate the hepatoprotective effect of ethanol extract of stem bark of Oroxylum indicum against carbon tetrachloride (CCl₄) induced hepatotoxicity. Research results show that the LD50 of the ethanol extract of stem bark of Oroxylum indicum could not be determined. After 8 days for oral administration, ethanol extract of stem bark of Oroxylum indicum at doses of 300mg/kg and 900mg/kg showed a hepatoprotective effect by reducing AST, ALT and MDA levels, in addition, a dose of 900mg/kg showed limited damage to the liver injury induced by CCl4 in a mice model. Through the study, we have the following conclusions the ethanol extract of stem bark of Oroxylum indicum is safe and exhibits hepatoprotective effects against CCl₄.