The Assessors of the Asian University Network - Quality Assurance (AUN-QA) are warmly welcomed!
Welcome to the Vietnamese Doctors’ Day!
Research / Publications
The cost-effectiveness of trivalent and quadrivalent influenza vaccination in communities in South Africa, Vietnam and Australia
Home Research Publications The cost-effectiveness of trivalent and quadrivalent influenza vaccination in communities in South Africa, Vietnam and Australia

The cost-effectiveness of trivalent and quadrivalent influenza vaccination in communities in South Africa, Vietnam and Australia

Pieter T.de Boer, Thi-Phuong-Lan Nguyen, Joel K. Kelso, Nilimesh Halder, Jocelyn Moyes, Cheryl Cohen, Ian G Barr, Maarten J Postma, George J Milne, Feb-2018, In: Vaccine, 36, 7, p. 997-1007

Overview

  • Pieter T.de Boer
  • Thi-Phuong-Lan Nguyen
  • Joel K. Kelso
  • Nilimesh Halder
  • Jocelyn Moyes
  • Cheryl Cohen
  • Ian G Barr
  • Maarten J Postma
  • George J Milne

Abstract:

Background: To inform national healthcare authorities whether quadrivalent influenza vaccines (QIVs) provide better value for money than trivalent influenza vaccines (TIVs), we assessed the cost-effectiveness of TIV and QIV in low-and-middle income communities based in South Africa and Vietnam and contrasted these findings with those from a high-income community in Australia.

Methods: Individual based dynamic simulation models were interfaced with a health economic analysis model to estimate the cost-effectiveness of vaccinating 15% of the population with QIV or TIV in each community over the period 2003-2013. Vaccination was prioritized for HIV-infected individuals, before elderly aged 65+ years and young children. Country or region-specific data on influenza-strain circulation, clinical outcomes and costs were obtained from published sources. The societal perspective was used and outcomes were expressed in International$ (I$) per quality-adjusted life-year (QALY) gained.

Results: When compared with TIV, we found that QIV would provide a greater reduction in influenza-related morbidity in communities in South Africa and Vietnam as compared with Australia. The incremental cost-effectiveness ratio of QIV versus TIV was estimated at I$4183/QALY in South Africa, I$1505/QALY in Vietnam and I$80,966/QALY in Australia.

Conclusions: The cost-effectiveness of QIV varied between communities due to differences in influenza epidemiology, comorbidities, and unit costs. Whether TIV or QIV is the most cost-effective alternative heavily depends on influenza B burden among subpopulations targeted forvaccination in addition to country-specific willingness-to-pay thresholds and budgetary impact.

Keyword(s): Cost-effectiveness; Dynamic transmission model; Influenza; Quadrivalent; Trivalent; Vaccination

Pages (from-to) 997-1007
Journal Vaccine
Volume 36
Issue number 7
Publication status Published - Feb-2018