The tall cell variant of papillary thyroid carcinoma with BRAF gene mutation (V600E): A case report in patient with thyroid goiter plunging mediastinum in VietDuc University Hospital
Overview
Abstract:
Papillary thyroid carcinoma is a very
popular malignant tumor in thyroid gland and is getting increased recently.
Papillary thyroid carcinoma consists of 15 variants with different histopathology,
immunohistochemistry, gene mutation, treatment and prognosis. The tall cell
variant of papillary thyroid carcinoma is a variant with high malignancy, poor
prognosis, developing in thyroid gland or extra thyroidal extension. Many
studies have shown that BRAF gene mutation is often found in this variant,
which is defined by molecular biology or immunohistochemistry with marker BRAF
(V600E). The detection of gene mutation helps the clinicians find suitable treatment
for patients. We report a case: a 58 year-old female patient, clinical
diagnosis of thyroid goiter plunging mediastinum, was operated to remove the
total tumor and left thyroid lobe, with histopathological characteristic of tall
cell variant of papillary thyroid carcinoma, stained immunohistochemistry with diffusely
and strongly positive result of BRAF (V600E).
Keyword(s): Thyroid papillary carcinoma, tall cell variant, BRAF gene mutation
Pages (from-to) | 51-56 |
Journal | Vietnam Journal of Oncology |
Issue number | 1 |
Publication status | Published - Apr-2021 |
ISBN | 1859-400X |